First of all, checkout the debut of the online sellers page. Some of the sites haven't listed whether or not they will have Black Friday promotions, so check them out and if you find anything, be sure to tell me.
Let's start off with the company with the biggest promotion this Black Friday.
Panini is really pushing a Black Friday promotion that includes special Black Friday packs. It looks like the rate will be one pack for each $25 spent. Here is a list of LCS's participating. Be sure to check if your LCS is running any sales Friday!
You can also participate by buying from the Panini store.
The big inclusions in the packs are Super Bowl XLV Relics and autos, a Marshall Faulk gold card, Tebow on-card autos, and numerous rookie cards.
Some cards have already been popping up on eBay.